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Anti -PAG (Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains 1, PAG1, Transmembrane Adapter Protein PAG, Csk-binding Protein, CBP, FLJ37858, MGC138364, Transmembrane Phosphoprotein Cbp)
Anti -PAG (Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains 1, PAG1,
Transmembrane Adapter Protein PAG, Csk-binding Protein, CBP, FLJ37858, MGC138364,
Transmembrane Phosphoprotein Cbp)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B |
|
| PAG1 is a 47kD protein that runs anomalously at 70-85kD in SDS PAGE. PAG1 is a constitutively phosphorylated and palmitoylated protein that occurs in leukocyte lipid rafts. It negatively regulates Src family kinases by linking Csk to FynT. Human PAG1 is 432aa in length. It is a type III (no signal sequence) transmembrane protein that contains a 16aa extracellular region aa1-16 and 395aa cytoplasmic domain aa38-432. PAG1 is palmitoylated at Cys37 and phosphorylated at Tyr317 where it interacts with Csk. There is an FynT binding site at aa131-137. One splice variant shows a 36aa substitution for aa293-432. | | | Catalog # | P1951-10E | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11n148 | | Host | Mouse | | Source | Human | | Concentration | Not determined | | Form | Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml. | | Purity | Purified by Protein A/G affinity chromatography. | | Immunogen | Recombinant corresponding to aa38-432 from human PAG1 expressed in E. coli (Q9NWQ8). | | Specificity | Recognizes human PAG1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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