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You are here:Home » Antibodies » Abs to Membrane Proteins » Anti -PAG (Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains 1, PAG1, Transmembrane Adapter Protein PAG, Csk-binding Protein, CBP, FLJ37858, MGC138364, Transmembrane Phosphoprotein Cbp)

Anti -PAG (Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains 1, PAG1,
Transmembrane Adapter Protein PAG, Csk-binding Protein, CBP, FLJ37858, MGC138364,
Transmembrane Phosphoprotein Cbp)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
PAG1 is a 47kD protein that runs anomalously at 70-85kD in SDS PAGE. PAG1 is a constitutively phosphorylated and palmitoylated protein that occurs in leukocyte lipid rafts. It negatively regulates Src family kinases by linking Csk to FynT. Human PAG1 is 432aa in length. It is a type III (no signal sequence) transmembrane protein that contains a 16aa extracellular region aa1-16 and 395aa cytoplasmic domain aa38-432. PAG1 is palmitoylated at Cys37 and phosphorylated at Tyr317 where it interacts with Csk. There is an FynT binding site at aa131-137. One splice variant shows a 36aa substitution for aa293-432.
Catalog #P1951-10E
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No11n148
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to aa38-432 from human PAG1 expressed in E. coli (Q9NWQ8).
SpecificityRecognizes human PAG1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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