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You are here:Home » Antibodies » Abs to GTPase, Rab, Ras, Rho Proteins » Anti -PAG3, phosphorylated (Tyr724) (Paxillin-associated Protein with ADP-ribosylation Factor GTPase-activating Protein 3)

Anti -PAG3, phosphorylated (Tyr724) (Paxillin-associated Protein with ADP-ribosylation
Factor GTPase-activating Protein 3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
PAG3 (paxillin-associated protein with ADP-ribosylation factor [ARF] GTPase-activating protein GAP] activity, number 3) is a member of the ARF GAP family of proteins that associates with the cytoskeleton, plays an important role in mediating actin cytoskeletal organization in response to adhesion and growth factor stimulation and is involved in paxillin subcellular localization. During monocyte maturation, the elevation of paxillin expression and integrin activation is associated with the induction of PAG3 expression. Overexpression of PAG3 inhibits paxillin recruitment to focal contacts and hinders cellular migration. PAG3 is phosphorylated by Pyk2 kinase on tyrosines 724 and 763.
Catalog #P1951-30
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlCOS cells overexpressing human wild-type PAG3, cotransfected with mouse Pyk2.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human PAG3 that contains tyrosine 724.
SpecificityRecognizes human PAG3 when phosphorylated at Tyr724. Species sequence homology: mouse (92%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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