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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified B

Pannexin 2 (PANX2) is a~60kD, 677aa protein of the pannexin family of four-transmembrane channel proteins with a conserved pattern of cysteines. PANX2 can interact with PANX1. It is mainly expressed on postnatal neural progenitors and is thought to inhibit the rate of neuronal differentiation. PANX2 expression is positively correlated with survival following glioma diagnosis, and it negatively regulates glioma cell line growth. Polymorphisms of PANX2 are associated with bipolar disorder and schizophrenia. Within aa316-456, human PANX2 shares 96% aa sequence identity with mouse and rat PANX2. A 643aa isoform diverges after 631aa, while a 509aa isoform also shows an alternate start site at 135aa.
Catalog #	P3075-01
Applications	Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution	Western Blot: 0.5ug/ml
	Optimal dilutions to be determined by the researcher.
Storage and Stability	Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG2B
Clone No	12K156
Host	Mouse
Source	Human
Concentration	~0.5mg/ml after reconstitution
Form	Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
Purity	Purified by Protein A/G affinity chromatography.
Immunogen	Recombinant corresponding to aa316-456 from human Pannexin-2 expressed in E.coli.
Specificity	Recognizes human Pannexin-2.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.