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You are here:Home » Antibodies » Abs to Infectious Disease Papilloma » Anti -Human Papilloma Virus Type 16 E7 (HPV)

Anti -Human Papilloma Virus Type 16 E7 (HPV)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Human papillomavirus (HPV) is a diverse group of DNA-based viruses that infect skin and mucous membranes of humans and animals. Some HPV types are the causative agents of cervical cancer, with types 16 and 18 being particularly high-risk. The viral proteins E6 and E7 disrupt normal cell cycle regulation by interacting with p53 (a tumor-suppressing transcription factor) and Rb (retinoblastoma protein, also a tumor-supressor). E7 particularly binds to Rb and histone deacetylases, resulting in activation of the E2F genes, which code for a family of transcription factors. The viral proteins E6 and E7 might be of particular interest in the development of therapeutic vaccines, since they are expressed early in viral infection.
Catalog #P3105-07A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
Matched PairSuitable for use as the capture or solid phase antibody.
Matched to P3105-16D, P3105-16F or P3105-25C as the detection or conjugate (label) antibody.
HybridomaSp2/0 myeloma cells with spleen cells from Balb/c mice.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No9B102
HostMouse
Concentration~2mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
PurityPurified by Protein G chromatography. >95% (SDS-PAGE).
ImmunogenHPV oncoprotein E7, type 16
SpecificityRecognizes Human Papilloma Virus Type16 (HPV16) E7 Protein. Crossreacts with HPV Type 18. Reacts with the monomer and dimer forms when tested in Western Blot.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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