You are here:Home
»
Antibodies
»
Abs to Infectious Disease Papilloma
»
Anti -Papilloma Virus Type 16 E7 Protein (E7, HPV16 E7, HpV16gp2, Links Transforming Protein Human Papillomavirus 16, Protein E7, Transforming Protein, Transforming Protein Human Papillomavirus 16)
Anti -Papilloma Virus Type 16 E7 Protein (E7, HPV16 E7, HpV16gp2, Links Transforming
Protein Human Papillomavirus 16, Protein E7, Transforming Protein, Transforming Protein
Human Papillomavirus 16)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
E B IH FC |
|
| Human papillomavirus (HPV) is a diverse group of DNA-based viruses that infect skin and mucous membranes of humans and animals. Some HPV types are the causative agents of cervical cancer, with types 16 and 18 being particularly high-risk. The viral proteins E6 and E7 disrupt normal cell cycle regulation by interacting with p53 (a tumor-suppressing transcription factor) and Rb (retinoblastoma protein, also a tumor-supressor). E7 particularly binds to Rb and histone deacetylases, resulting in activation of the E2F genes, which code for a family of transcription factors. The viral proteins E6 and E7 might be of particular interest in the development of therapeutic vaccines, since they are expressed early in viral infection. | | | Catalog # | P3105-17Y | | Applications | Suitable for use in Flow Cytometry, ELISA, Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry: frozen sections | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 9A277 | | Host | Mouse | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2. No preservative added. | | Purity | Purified | | Immunogen | Full length protein (HPV 16 E7) synthesized from S. pombe. | | Specificity | Recognizes Human papilloma virus Type 16 E7 protein at ~15kD. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
