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You are here:Home » Antibodies » Abs to Infectious Disease Papilloma » Anti -Papilloma Virus Type 16 E7 Protein (E7, HPV16 E7, HpV16gp2, Links Transforming Protein Human Papillomavirus 16, Protein E7, Transforming Protein, Transforming Protein Human Papillomavirus 16)

Anti -Papilloma Virus Type 16 E7 Protein (E7, HPV16 E7, HpV16gp2, Links Transforming
Protein Human Papillomavirus 16, Protein E7, Transforming Protein, Transforming Protein
Human Papillomavirus 16)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse E B
Human papillomavirus (HPV) is a diverse group of DNA-based viruses that infect skin and mucous membranes of humans and animals. Some HPV types are the causative agents of cervical cancer, with types 16 and 18 being particularly high-risk. The viral proteins E6 and E7 disrupt normal cell cycle regulation by interacting with p53 (a tumor-suppressing transcription factor) and Rb (retinoblastoma protein, also a tumor-supressor). E7 particularly binds to Rb and histone deacetylases, resulting in activation of the E2F genes, which code for a family of transcription factors. The viral proteins E6 and E7 might be of particular interest in the development of therapeutic vaccines, since they are expressed early in viral infection.
Catalog #P3105-17Y1
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:2000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No9A278
HostMouse
Concentration~10mg/ml
FormSupplied as a liquid in PBS, pH 7.2.
PurityAs reported
ImmunogenFull size recombinant E7 protein of HPV type 16.
SpecificityRecognizes the E7 protein of HPV type 16. Crossreacts with E7 protein of HPV type 18. Species Crossreactivity: Human Papilloma Virus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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