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You are here:Home » Antibodies » Abs to Infectious Disease Papilloma » Anti -Papilloma Virus, Human, Type 18, Early Protein 7 (hPV, HPV18 E7, E7 Protein)

Anti -Papilloma Virus, Human, Type 18, Early Protein 7 (hPV, HPV18 E7, E7 Protein)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Human papillomavirus (HPV) is a diverse group of DNA-based viruses that infect skin and mucous membranes of humans and animals. Type 11 HPV is a low risk type that causes anogenital warts and is not linked with cervical cancer. In rare cases HPV-11 may cause respiratory papillomatosis, where warts form on the larynx or other areas of the respiratory tract. The viral protein E7 binds to Rb (retinoblastoma protein) and histone deacetylases, resulting in activation of the E2F genes, which code for a family of transcription factors. This binding is of much lower affinity than the high-risk HPV E7 proteins. The viral proteins E6 and E7 might be of particular interest in the development of therapeutic vaccines, since they are expressed early in viral infection.
Catalog #P3105-24C
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No10F272
HostMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenOncoprotein E7 from human papillomavirus 18.
SpecificityRecognizes the E7 oncoprotein of human papilloma virus 18. Does not cross-react with the E7 protein of HPV-16.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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