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You are here:Home » Antibodies » Antibodies-Hormones, Steroids » Anti -Parathyroid hormone receptor 1 (PTH/PTHr receptor, PTH1 R)

Anti -Parathyroid hormone receptor 1 (PTH/PTHr receptor, PTH1 R)


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Clone Host Grade Applications
Polyclonal Sheep Affinity Purified E B IH
PTH1 R (Parathyroid hormone receptor 1; also PTH/PTHr receptor) is a predicted 66-68kD member of the G-protein coupled receptor family 2. It is expressed on a variety of cell types, including hepatocytes, renal epithelium, smooth muscle cells, and osteoblasts plus chondrocytes. PTH1 R is a receptor for both PTH and PTHrP, and PTH binding promotes Ca ++ -release from bone, mediated by osteoclast formation. Mature human PTH1 R is a 7-transmembrane glycoprotein 567 amino acids (aa) in length. It contains a long, ligand-binding N-terminal extracellular region (aa 27-188) and a 130 aa cytoplasmic C-terminal domain. Single aa changes such as Gly121Glu, Ala122Thr and Arg255His can impair PTH1 R signaling.
Catalog #P3109-51C
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 0.5-1.0ug/ml
Western Blot: 1.0ug/ml
Immunohistochemistry: 3-10ug/ml. Antigen retrieval is recommended.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
FormSupplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 500ul sterile PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenCHO cell-derived, recombinant human PTH1 R extracellular domain aa23-189 (Accession #Q03431).
SpecificityRecognizes human Parathyroid hormone receptor 1. Species sequence homology: mouse, 88%.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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