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You are here:Home » Antibodies » Antibodies-Oncoproteins » Anti -PARK7 (CAP1, DJ1, DJ-1, DJ1 Protein, FLJ27376, Oncogene DJ1, Parkinson Disease (Autosomal Recessive Early Onset) 7, Protein DJ-1, RNA Binding Protein Regulatory Subunit, SP22)

Anti -PARK7 (CAP1, DJ1, DJ-1, DJ1 Protein, FLJ27376, Oncogene DJ1, Parkinson Disease
(Autosomal Recessive Early Onset) 7, Protein DJ-1, RNA Binding Protein Regulatory Subunit,


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP IH IC IF
PARK7/DJ1 is a ubiquitously expressed protein involved in various cellular processes including cell proliferation, RNA-binding, and oxidative stress. The protein has been found to colocalize within a subset of pathologic tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies (Rizzu et al. 2004). Four chromosomal loci (PARK2, PARK6, PARK7, and PARK9) associated with autosomal recessive, early onset parkinsonism are known. Positional cloning within the refined PARK7 critical region recently identified mutations in the DJ-1 gene in PARK7-linked families. Defects in PARK7/DJ1 are the cause of autosomal recessive early-onset Parkinson's disease 7 (PARK7). Parkinson's disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years. The disease is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK7 is characterized by onset before 40 years and slow progression. It has also been suggested that PARK7/DJ1 is a mitogen dependent oncogene product involved in Ras related signal transduction pathways.
Catalog #P3110-99K
ApplicationsSuitable for use in Western Blot, Immunohistochemistry, Immunofluorescence/Immunocytochemistry and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry: 1:1000
Immunohistochemistry (paraffin): 1:1000 Requires HIER using sodium citrate buffer pH6.0
Immunofluorescence (IC): 1:100-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to a sequence within aa100-189 of the human PARK7 (DJ-1) protein (Q99497). Species Sequence Homology: monkey 100%, chicken and porcine 86%
SpecificityRecognizes human PARK7. Species Crossreactivity: rat and mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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