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You are here:Home » Antibodies » Antibodies-Ubiquitin Ligases » Anti -Parkin, aa305-323 (RING-type E3 ubiquitin-protein ligase)

Anti -Parkin, aa305-323 (RING-type E3 ubiquitin-protein ligase)


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Clone Host Grade Applications
Polyclonal Rabbit Serum E IH
Parkinsonís disease, a common neurodegenerative disease is caused by slow death of neurons in the substantial nigra, a brain region that utilizes the neurotransmitter dopamine. Parkin, a recently discovered gene encoding a large protein, may be involved in normal and abnormal protein degradation in cells. Recent evidence indicates that point mutations in the Parkin gene appears to be responsible for the pathogenesis of some forms of Parkinsonís disease. The Parkin protein is expressed in various regions of the brain, including the substantia nigra, and is also expressed in other tissues, including heart, testes and skeletal muscle. This protein may function in the control of cell growth, differentiation and development.
Catalog #P3111-01
Parkin is a protein of 465 amino acids with an amino-terminal ubiquitin domain and a carboxy-terminal RING-box (1). In the case of autosomal recessive juvenile Parkinsonism (AR-JP), deletions have been found in the gene on chromosome 6 encoding the protein Parkin.
Immunohistochemistry One site ELISA
Clone TypePolyclonal
ConcentrationNot determined
FormLyophilized. Reconstitute with 50ul of sterile distilled water. Centrifuge to remove insoluble material. Contains no preservative.
ImmunogenA 19 amino acid peptide (RILGEEQYNRYQQYGAEEC) corresponding to sequence number 305Ė323 of the human parkin molecule. An internal peptide sequence was chosen to avoid the possibility of cross reactivity with ubiquitin.
Species ReactivityHuman and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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