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You are here:Home » Antibodies » Abs to Ubiquitin Ligases » Anti -Parkin (AR-JP, E3 Ubiquitin Protein Ligase Parkin, FRA6E, LPRS2, Parkinson Disease (Autosomal Recessive, Juvenile) 2, Parkinson Disease Protein 2, Parkinson Juvenile Disease Protein 2, PARK2, PRKN 2, PRKN, PDJ, RING-type E3 Ubiquitin-protein Ligase, Ubiqu

Anti -Parkin (AR-JP, E3 Ubiquitin Protein Ligase Parkin, FRA6E, LPRS2, Parkinson Disease
(Autosomal Recessive, Juvenile) 2, Parkinson Disease Protein 2, Parkinson Juvenile Disease
Protein 2, PARK2, PRKN 2, PRKN, PDJ, RING-type E3 Ubiquitin-protein Ligase, Ubiqu

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IH
Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene.
Catalog #P3112-02M
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormReconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.
PuritySerum
ImmunogenA synthetic peptide (RILGEE QYNRYQQYGA EEC) as part of human Parkin conjugated to diphtheria toxoid.
SpecificitySpecifically recognizes Parkin shown by IHC and WB. Species Crossreactivity: Human, guinea pig and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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