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You are here:Home » Antibodies » Abs to Ubiquitin Ligases » Anti -Parkin, phosphorylated (Ser378) (AR-JP, E3 Ubiquitin Protein Ligase Parkin, FRA6E, LPRS2, Parkinson Disease (Autosomal Recessive, Juvenile) 2, Parkinson Disease Protein 2, Parkinson Juvenile Disease Protein 2, PARK2, PRKN 2, PRKN, PDJ, RING-type E3 Ubiqui

Anti -Parkin, phosphorylated (Ser378) (AR-JP, E3 Ubiquitin Protein Ligase Parkin, FRA6E,
LPRS2, Parkinson Disease (Autosomal Recessive, Juvenile) 2, Parkinson Disease Protein 2,
Parkinson Juvenile Disease Protein 2, PARK2, PRKN 2, PRKN, PDJ, RING-type E3 Ubiqui

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Parkin is an E3 ubiquitin ligase highly expressed in the brain, which functions in the ubiquitin-proteasome system, together with the E2 ubiquitin conjugating co-enzyme UbcH7. Mutations in theparkin gene are associated with the hereditary neurodegenerative disorder known as autosomal recessive early onset Parkinson disease 2 (PARK2)/autosomal recessive juvenile Parkinson disease (PDJ), characterized by progressive dopaminergic neural cell death. Studies have identified the presence of at least fivephosphorylation sites in parkin including er101, shown to be phosphorylated by Casein kinase-1 (CK-1), and suggest thatphosphorylation of parkin may act to regulate its ubiquitin ligase activity.
Catalog #P3112-02P
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in10mM HEPES, pH 7.5, 0.09% sodium azide, 0.01% BSA, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to an aa sequence within parkin, which includes phosphorylated Ser378.
SpecificityRecognizes human parkin protein, when phosphorylated at Ser378.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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