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You are here:Home » Antibodies » Abs to Ubiquitin Ligases » Anti -Parkin, R2 Domain (RING-type E3 ubiquitin-protein ligase)

Anti -Parkin, R2 Domain (RING-type E3 ubiquitin-protein ligase)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Parkin is a ubiquitin-protein isopeptide ligase (E3) involved in ubiquitin/proteasome-mediated protein degradation. Parkin may protect cells from premature death by targeting misfolded or damaged proteins for degradation via the ubiquitin proteasome pathway. Mutations in the parkin gene cause a loss-of-function and/or alter protein levels of parkin. The loss of functional parkin is the most common single cause of autosomal recessive Parkinson's disease. Parkin expression is neuron-specific and developmentally regulated, and thus, has a role in neuronal maturation. Parkin may also play roles in cell cycle regulation and tumor suppression.
Catalog #P3112-03H
ApplicationsSuitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No9L529
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS. No preservative added.
PurityPurified by Protein A affinity chromatography.
ImmunogenHuman Parkin, R2 domain.
SpecificityRecognizes the R2 domain of human Parkin. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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