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You are here:Home » Antibodies » Abs to Enzymes, Polymerase » Anti -PARP (Poly ADP-Ribose Polymerase)

Anti -PARP (Poly ADP-Ribose Polymerase)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Poly ADP-Ribose Polymerase (PARP). PARP uses nicotinamide adenine dinucleotide (oxidized form) NAD as a substrate to catalyse the transfer of ADP-ribose to a variety of nuclear protein acceptors. Proteolysis of PARP to its stable 85kD fragment is an early marker of programmed cell death (apoptosis) and is mediated by the caspase CPP32 protein. Cleavage occurs between Adp216 and Gly217, a site in PARP conserved across species.
Catalog #P3113-01K
Epitope C-terminal
ApplicationsWestern Blot: (Ab 5-10ug/ml for 2hrs at RT).
Positive Control Raji cells
Cellular Localization Nuclear
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceBovine
Concentration~1mg/ml
FormSupplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA and 0.09% sodium azide. Also available without BSA and azide at 1mg/ml. See P3113-01K1.
PurityPurified by Protein A affinity chromatography.
ImmunogenA synthetic peptide from the C-terminal region of bovine PARP.
SpecificityRecognizes PARP. Species Crossreactivity: Human, Mouse, Rat and Bovine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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