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You are here:Home » Antibodies » Abs to Calcium Binding Proteins » Anti -Parvalbumin (PVALB, D22S749, HGNC:9704, MGC116759, Parvalbumin alpha)

Anti -Parvalbumin (PVALB, D22S749, HGNC:9704, MGC116759, Parvalbumin alpha)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IP IH
Parvalbumin (PV) is a calcium binding protein expressed in specific muscle fibers and fast-firing neurons. PV consists of a single, unbranched chain of linked amino acids and belongs to a larger group of EF hand proteins. Studies have demonstrated that parvalbumin acts in the decay of calcium in the contraction/ relaxation cycle of fast twitch muscles. This data has shown a positive correlation between the rate of relaxation and the concentration of parvalbumin. Parvalbumin is also expressed in a specific population of GABAergic interneurones which are thought to play a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus. In amyotrophic lateral sclerosis (ALS) patents, parvalbumin immunoreactivity is specifically absent from neuron populations lost early in ALS.
Catalog #P3113-51B
ApplicationsSuitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 0.1ug/ml. Detects a band of ~12kD, representing parvalbumin from rat cerebellum. Since this protein is relatively small, it is recommended that electrophoresis be performed using tricine-SDS-PAGE gels and transferred to a nylon membrane.
Immunoprecipitation: 5ug/ml
Immunohistochemistry (Paraffin): 1ug/ml
Immunohistochemistry: Frozen sections
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 15mg/ml BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenPurified parvalbumin from rat skeletal muscle.
Cellular LocalizationCytoplasmic and Nuclear
SpecificityRecognizes rat Parvalbumin. Species Crossreactivity: human
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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