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You are here:Home » Antibodies » Abs to Extracellular Matrix Proteins » Anti -Parvin alpha, phosphorylated (Ser8) (PARVA, Alpha-Parvin, Actopaxin, Calponin-like Integrin-linked Kinase-binding Protein, CH-ILKBP, FLJ10793, FLJ12254, Matrix Remodelling-associated Protein 2, MXRA2)

Anti -Parvin alpha, phosphorylated (Ser8) (PARVA, Alpha-Parvin, Actopaxin, Calponin-like
Integrin-linked Kinase-binding Protein, CH-ILKBP, FLJ10793, FLJ12254, Matrix
Remodelling-associated Protein 2, MXRA2)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IC
Actopaxin (also named Parvin, Parva) is a member of the alpha actinin superfamily containing a single alpha-actinin-like actin-binding domain. The Parvin family plays a role in cell adhesion and cytoskeleton organization. Analysis of Actopaxin and its para- and orthologues suggest, that the parvins represent a new family of alpha-actinin-related proteins that mediate cell-matrix adhesion (1).
Actopaxin as a widely expressed protein that binds directly to both F-actin and paxillin LD1 and LD4 motifs. It exhibits robust focal adhesion localization in several cultured cell types but is not found along the length of the associated actin-rich stress fibers. Actopaxin colocalizes with paxillin to rudimentary focal complexes at the leading edge of migrating cells. Results suggest an important role for actopaxin in integrin-dependent remodeling of the actin cytoskeleton
during cell motility and cell adhesion (2).
Catalog #P3113-60B
ApplicationsSuitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:2500-1:5000
Immunocytochemistry: 1:100-1:250
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9H494
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
PuritySupernatant
ImmunogenA phospho specific peptide corresponding to residues surrounding serine 8 of human Parvin
SpecificityRecognizes human Actopaxin phosphorlyated on serine 8. Species Crossreactivity: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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