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Specifications

Clone Host Grade Applications Polyclonal Sheep Affinity Purified B

The cytoskeletal adaptor protein Paxillin is found at the interface between actin filaments and the plasma membrane. Paxillin localizes to focal adhesions, where it provides a platform for the integration and coordination of adhesion- and growth factor-related signals. Paxillin phosphorylation is required for integrin-mediated cytoskeletal reorganization, and may play a role in the disassembly of focal adhesions and stress fibers during cellular transformation. Increased Paxillin protein levels have also been reported in several malignancies, including renal, lung and breast carcinomas.
Catalog #	P3113-90C
Applications	Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution	Western Blot: 1ug/ml
	Optimal dilutions to be determined by the researcher.
Recommended Secondary Antibodies	I1904-61G: IgG H&L, X-adsorbed (HRP) Pab DkxSh
	I1904-63: IgG H&L (HRP) Pab DkxSh
Storage and Stability	Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS, 0.02% sodium azide. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Sheep
Source	Human
Concentration	Not determined
Form	Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with sterile PBS, 0.02% SODIUM AZIDE.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Partial recombinant human Paxillin, aa59-274 expressed in E. coli (P49023).
Specificity	Recognizes human Paxillin. Species Crossreactivity: Mouse and rat.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.