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You are here:Home » Antibodies » Abs to Paxillin » Anti -Paxillin (PXN)

Anti -Paxillin (PXN)

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Affinity Purified B
The cytoskeletal adaptor protein Paxillin is found at the interface between actin filaments and the plasma membrane. Paxillin localizes to focal adhesions, where it provides a platform for the integration and coordination of adhesion- and growth factor-related signals. Paxillin phosphorylation is required for integrin-mediated cytoskeletal reorganization, and may play a role in the disassembly of focal adhesions and stress fibers during cellular transformation. Increased Paxillin protein levels have also been reported in several malignancies, including renal, lung and breast carcinomas.
Catalog #P3113-90C
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Recommended Secondary AntibodiesI1904-61G: IgG H&L, X-adsorbed (HRP) Pab DkxSh
I1904-63: IgG H&L (HRP) Pab DkxSh
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS, 0.02% sodium azide. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with sterile PBS, 0.02% SODIUM AZIDE.
PurityPurified by immunoaffinity chromatography.
ImmunogenPartial recombinant human Paxillin, aa59-274 expressed in E. coli (P49023).
SpecificityRecognizes human Paxillin. Species Crossreactivity: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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