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Specifications

Clone Host Grade Applications Monoclonal Mouse Ascites B IP IH

Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p120BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion, consistent with the belief that paxillin is involved in the regulation of cell morphology. Additionally because of is SH3-binding domain, paxillin associates tightly with FAK and Crk in a manner that is independent of the extracellular matrix. Although paxillin was initially detected in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.
Catalog #	P3113-90D
Applications	Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended Dilution	Western Blot: 1ug/ml
	Immunohistochemistry (formalin fixed paraffin embedded): 1:50-1:100
	Immunoprecipitation: 2ug/mg
	Immunohistochemistry: Frozen
	Optimal dilutions to be determined by the researcher.
Positive Control	Colon carcinoma
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	11E312
Host	Mouse
Source	Human
Concentration	Not determined.
Form	Supplied as a liquid, 0.05% sodium azide.
Purity	Ascites
Immunogen	Recombinant corresponding to full length, purified human paxillin. Cellular Localization: Cell membrane, cytoplasmic.
Specificity	Recognizes human Paxillin. Species Crossreactivity: bovine, avian, rat.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.