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You are here:Home » Antibodies » Abs to Paxillin » Anti -Paxillin, phosphorylated, Tyr31 (PXN)

Anti -Paxillin, phosphorylated, Tyr31 (PXN)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Paxillin is a 68kD cytoskeletal adapter protein involved in organization and function of focal
adhesions, which are critical to cell adhesion and migration. This in turn plays a role in a wide
variety of processes including embryogenesis, organogenesis, wound repair, inflammation and
cancer. Paxillin contains LD motifs, LIM domains, SH3 and SH2 binding domains that serve as
docking sites for cytoskeletal proteins, tyrosine kinases (e.g., FAK, Pyk2, Src), serine/threonine
kinases, GTPase activating proteins and other adaptor proteins (e.g., actin, vinculin, Crk). Tyrosine
31, a Crk binding site of paxillin, is phosphorylated during integrin-mediated cell adhesion.
Catalog #P3113-90Y
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlNMuMG cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human paxillin that contains tyrosine 31.
SpecificityRecognizes mouse paxillin when phosphorylated at Tyr31. Species sequence homology: Human (100%) and chicken (93%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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