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You are here:Home » Antibodies » Abs to Paxillin » Anti -Paxillin (PXN)

Anti -Paxillin (PXN)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
Paxillin is a protein with 4 LIM domains, a proline-rich domain containing consensus SH3-binding site, and 3 potential SH2-binding sites. It acts as an ERK-regulated scaffold that coordinates FAK and Rac activation in epithelial morphogenesis. Paxillin is a novel vinculin-binding protein present in focal adhesions and its isoforms in monocyte and cancer cells are known to have different binding properties to focal adhesion proteins. Paxillin binds to schwannomin and regulates its density-dependent localization and effect on cell morphology. Phosphorylation of Paxillin by JNK is known to regulate cell migration. The human Paxillin gene is localized in the chromosomal region 12q24.31.
Catalog #P3113-91H
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa112-126 ([BLAST]VGEEEHVYSFPNKQK[BLAST]) of human Paxillin.
SpecificityRecognizes human Paxillin. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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