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You are here:Home » Antibodies » Abs to Obesity Proteins » Anti -PBEF (Pre-B cell Colony Enhancing Factor, Pre-B cell Enhancing Factor, Nicotinamide Phosphoribosyltransferase, NAmPRTase, NAMPT, Pre-B cell Colony Enhancing Factor 1, PBEF1, Visfatin, VF)

Anti -PBEF (Pre-B cell Colony Enhancing Factor, Pre-B cell Enhancing Factor, Nicotinamide
Phosphoribosyltransferase, NAmPRTase, NAMPT, Pre-B cell Colony Enhancing Factor 1, PBEF1,
Visfatin, VF)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B
NAMPT is a 491aa adipokine belonging to the NAPRTase family. It promotes angiogenesis via activation of the mitogen-activated protein kinase ERK-dependent pathway, is upregulated in neutrophils by IL-1beta, and functions as a novel inhibitor of apoptosis in response to a variety of inflammatory stimuli. It acts as a regulator of NAD+-dependent reactions in smooth muscle cells (SMCs) and in the pathogenesis of type 2 diabetes mellitus. NAMPT plays a role in insulin resistance and markers of hyperandrogenism in lean PCOS patients. It is a longevity protein that can add stress-resistant life to human smooth muscle cells by optimizing SIRT1-mediated p53 degradation. The expression level of NAMPT is high in visceral fat and serum levels in overweight and obese subjects with metabolic syndrome. It is expressed in large amounts in bone marrow, liver tissue, muscle, heart, placenta, lung and kidney tissues.
Catalog #P3113-97D7
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:5000
Optimal dilutions to be determined by the researcher.
Positive ControlSkeletal muscle lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa30-80 of human PBEF.
SpecificityRecognizes human PBEF. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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