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You are here:Home » Antibodies » Antibodies-Enzymes, Isomerase » Anti -PDI (Protein Disulfide Isomerase)

Anti -PDI (Protein Disulfide Isomerase)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH IC IF
The mammalian protein disulfide-isomerase (PDI) family encompasses several highly divergent proteins involved in the processing and maturation of secretory proteins in the ER by catalyzing the rearrangement of disulfide bonds. PDI, an abundant protein of the ER (> 400uM), contains a carboxy-terminal retention signal sequence, KDEL, similar to that of BiP and Grp94. The PDI proteins are characterized by the presence of one or more domains of ~95-110 amino acids related to the cytoplasmic protein thioredoxin. All but the PDI-D subfamily are composed entirely of repeats of such domains, with at least one domain containing and one domain lacking a redox-active-Cys-X-X-Cys-tetrapeptide (1). In addition to their roles as redox catalysts and isomerases, PDI proteins have other functions such as peptide binding, cell adhesion and perhaps chaperone activities. Platelet surface thiols and disulfides play an important role in platelet responses. Catalytically active PDI is found on platelet surfaces where it has been demonstrated to mediate platelet aggregation and secretion possible by reducing disulfide bonds thus leading to exposure of fibrinogen receptors in platelets.
Suitable for use in Western Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Electron Microscopy and Fluorescence Microscopy. Other applications not tested.
Catalog #P3122-10
Recommended DilutionsWestern Blot (Colorimetric): 1:1000
Immunohistochemistry: 1:200-1:500
Optimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No4E177
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide, 50% glycerol.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to the sequence near the C-terminus of rat protein disulfide isomerase.
SpecificityRecognizes rat protein disulfide isomerase at ~58kD.
Species CrossreactivityHuman, mouse, bovine, chicken, canine, guinea pig, hamster, monkey, porcine, rabbit, sheep and Xenopus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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