Anti -Pdx1 (Pdx Family Homeodomain Transcription Factor, Pancreas/Duodenum Homeobox 1,
Glucose Sensitive Factor, GSF, Insulin Promoter Factor 1, IPF1, Islet/Duodenum Homeobox 1,
IDX1, Insulin Upstream Factor 1, IUF1, MODY4, Somatostatin Transactivating Factor 1
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B IC |
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| PDX-1 (Pancreas-duodenum homeobox 1; also IPF-1, IDX-1, STF-1, GSF and IUF-1) is a 42kD member of the IPF-1 subfamily, ANTP homeobox family of proteins. It is expressed in developing pancreas, plus pancreatic beta-cells, and duodenal crypt epithelium. In concert with HNF6, PDX-1 drives pancreatic endocrine cell formation by regulating the expression of neurogenin-3. In adult beta-cells, PDX-1 binds to PCIF-1 to regulate insulin production. Mouse PDX-1 is 284aa in length (Accession # P52946). It contains one transactivation domain (aa13-73) a PBX1 P-P-M-W-K dimerization motif (aa119-124), and a DNA-binding homeodomain with an embedded NLS (aa148-206). Full-length mouse PDX-1 shares 94% and 88% aa identity with rat and human PDX-1, respectively. | | | Catalog # | P3127-05A | | Applications | Suitable for use in ELISA, Immunocytochemistry, and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 0.5-1ug/ml | | Western Blot: 1ug/ml | | Immunocytochemistry: 10ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C for short-term only. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Mouse | | Concentration | As reported | | Form | Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with sterile PBS. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Purified, E. coli-derived recombinant mouse Pancrease/Duodenum Homeobox-1 (aa1-284; Accession # P52946). | | Specificity | Recognizes mouse Pdx1. Species Crossreactivity: rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Pdx1 (Pdx Family Homeodomain Transcription Factor, Pancreas/Duodenum Homeobox 1, Glucose Sensitive Factor, GSF, Insulin Promoter Factor 1, IPF1, Islet/Duodenum Homeobox 1, IDX1, Insulin Upstream Factor 1, IUF1, MODY4, Somatostatin Transactivating Factor 1 |
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