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You are here:Home » Antibodies » Abs to Transcription Factors, Homeobox (HOX) » Anti -Pdx1 (Pdx Family Homeodomain Transcription Factor, Pancreas/Duodenum Homeobox 1, Glucose Sensitive Factor, GSF, Insulin Promoter Factor 1, IPF1, Islet/Duodenum Homeobox 1, IDX1, Insulin Upstream Factor 1, IUF1, MODY4, Somatostatin Transactivating Factor 1

Anti -Pdx1 (Pdx Family Homeodomain Transcription Factor, Pancreas/Duodenum Homeobox 1,
Glucose Sensitive Factor, GSF, Insulin Promoter Factor 1, IPF1, Islet/Duodenum Homeobox 1,
IDX1, Insulin Upstream Factor 1, IUF1, MODY4, Somatostatin Transactivating Factor 1

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B IC
PDX-1 (Pancreas-duodenum homeobox 1; also IPF-1, IDX-1, STF-1, GSF and IUF-1) is a 42kD member of the IPF-1 subfamily, ANTP homeobox family of proteins. It is expressed in developing pancreas, plus pancreatic beta-cells, and duodenal crypt epithelium. In concert with HNF6, PDX-1 drives pancreatic endocrine cell formation by regulating the expression of neurogenin-3. In adult beta-cells, PDX-1 binds to PCIF-1 to regulate insulin production. Mouse PDX-1 is 284aa in length (Accession # P52946). It contains one transactivation domain (aa13-73) a PBX1 P-P-M-W-K dimerization motif (aa119-124), and a DNA-binding homeodomain with an embedded NLS (aa148-206). Full-length mouse PDX-1 shares 94% and 88% aa identity with rat and human PDX-1, respectively.
Catalog #P3127-05A
ApplicationsSuitable for use in ELISA, Immunocytochemistry, and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.5-1ug/ml
Western Blot: 1ug/ml
Immunocytochemistry: 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C for short-term only. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceMouse
ConcentrationAs reported
FormSupplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with sterile PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenPurified, E. coli-derived recombinant mouse Pancrease/Duodenum Homeobox-1 (aa1-284; Accession # P52946).
SpecificityRecognizes mouse Pdx1. Species Crossreactivity: rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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