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You are here:Home » Molecular Biology » MB-Protease Inhibitors » PEDF, Recombinant, Human (Pigment Epithelial Derived Factor, SerpinF1, EPC-1)

PEDF, Recombinant, Human (Pigment Epithelial Derived Factor, SerpinF1, EPC-1)

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Specifications

Recombinant Human PEDF (Pigment epithelium-derived factor, SerpinF1, EPC-1) is a noninhibitory serpin with neurotrophic, anti- angiogenic, and anti-tumorigenic properties. It is a 50kD glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti- angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins.
Catalog #P3140-02A
The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers.
Recombinant PEDF is a 44.5kD non-glycosylated protein containing 400 amino acid residues.
SourceRecombinant human PEDF (pigment epithelium-derived factor) expressed in E. coli cells..
Biological Activity Data Not Available
AA Sequence MQNPASPPEE GSPDPDSTGA LVEEEDPFFK VPVNKLAAAV
SNFGYDLYRV RSSMSPTTNV LLSPLSVATA LSALSLGAEQ RTESIIHRAL YYDLISSPDI HGTYKELLDT VTAPQKNLKS ASRIVFEKKL RIKSSFVAPL EKSYGTRPRV LTGNPRLDLQ EINNWVQAQM KGKLARSTKE IPDEISILLL GVAHFKGQWV TKFDSRKTSL EDFYLDEERT VRVPMMSDPK AVLRYGLDSD LSCKIAQLPL TGSMSIIFFL PLKVTQNLTL IEESLTSEFI HDIDRELKTV QAVLTVPKLK LSYEGEVTKS LQEMKLQSLF DSPDFSKITG KPIKLTQVEH RAGFEWNEDG AGTTPSPGLQ
PAHLTFPLDY HLNQPFIFVL RDTDTGALLF IGKILDPRGP
Endotoxin 0.1ng/ug (1EU/ug).
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight44.5kD
SourceE. coli
Purity90% by SDS-PAGE, HPLC
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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