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You are here:Home » Antibodies » Abs to Enzymes, Protease (Proteinase, Peptidase) » Anti -Pepsinogen I

Anti -Pepsinogen I

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E RIA
Pepsinogen I, a zymogen, or proenzyme secreted by Chief cells in the stomach, is cleaved to form pepsin both in an autocatalytic fashion and by pepsin itself. In humans there are two related forms of pepsin, Pepsinogen I, also known as Pepsinogen A, and Pepsinogen II, also known as Pepsinogen B or progastricsin.
Catalog #P3272-06
A protein precursor to pepsin, Pepsinogen I or Pepsinogen A is secreted exclusively by the chief cells of the gastric corpus. The levels of Pepsinogen I correlate directly with the active number of chief cells in this area. In cases of severe atrophic gastritis of the corpus region, the chief cells will be destroyed and the levels of Pepsinogen I will fall dramatically.
ApplicationsSuitable for use in ELISA and RIA. Other applications have not been tested.
Recommended DilutionELISA: Direct and sandwich.
Optimal dilutions to be determined by the researcher.
Affinity Constant4x10e10L/mol
Recommended Secondary AntibodiesI1904-06C: IgG, H&L (HRP) (X-Adsorbed) Pab Gt xMo
I1904-06H IgG, H&L (HRP) (X-Adsorbed) Pab Gt xMo
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8.BG.1
HostMouse
SourceHuman
Concentration~0.25mg/ml
FormSupplied as a liquid in PBS, 0.09% sodium azide, before the addition of glycerol to 40%.
PurityPurified by Protein A affinity chromatography.
ImmunogenHuman pepsinogen I (native).
SpecificityRecognizes human pepsinogen I, both zymogen and proenzyme.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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