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You are here:Home » Antibodies » Abs to Enzymes, Protease (Proteinase, Peptidase) » Anti -Pepsinogen II

Anti -Pepsinogen II

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
Pepsinogen II or pepsinogen C belongs to a group of aspartic proteinase zymogens (inactive form) that are activated in the acid pH of stomach to active enzyme pepsin. Pepsinogen II (PG II) is produced by chief cells and mucus neck cells of gastric mucosa, pyloric glands in the antrum and Brunner's glands in the proximal duodenum. Serum concentration of PG II reflects the histological status of gastric mucosa. The ratio of concentration of PGI to PGII in serum of normal subjects is about 4:1. The PGI/PGII ratio decreases linearly with increasing grade of atrophic gastritis in the corpus. The ratio is < 2.5 when the atrophic gastritis is advanced (moderate or severe) in the gastric corpus.
Catalog #P3272-06A
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Affinity Constant3x10e10 1/mol human pepsinogen II.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8.BG.4
HostMouse
SourceHuman
Concentration~0.2mg/ml
FormSupplied as a liquid in citrate-sodium chloride buffer, pH 6.0, 0.09% sodium azide, before the addition of glycerol to 40%.
PurityPurified by affinity chromatography.
ImmunogenHuman pepsinogen II
SpecificityRecognizes human pepsinogen II.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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