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You are here:Home » Antibodies » Antibodies-Enzymes, Protease (Proteinase, Peptidase) » Anti -Pepsinogen II

Anti -Pepsinogen II


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Pepsinogen II or pepsinogen C belongs to a group of aspartic proteinase zymogens (inactive form) that are activated in the acid pH of stomach to active enzyme pepsin. Pepsinogen II (PG II) is produced by chief cells and mucus neck cells of gastric mucosa, pyloric glands in the antrum and Brunner's glands in the proximal duodenum. Serum concentration of PG II reflects the histological status of gastric mucosa. The ratio of concentration of PGI to PGII in serum of normal subjects is about 4:1. The PGI/PGII ratio decreases linearly with increasing grade of atrophic gastritis in the corpus. The ratio is < 2.5 when the atrophic gastritis is advanced (moderate or severe) in the gastric corpus.
Catalog #P3272-07
ApplicationsSuitable for use in Immunohistochemistry, Western Blot and ELISA. Other applications not tested.
Recommended DilutionImmunohistochemistry: Paraffin sections
Optimal dilutions to be determined by the researcher.
HybridomaProduced by the fusion between myeloma cells and Balb/c spleen cells.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No5G19
FormSupplied as a liquid in PBS, pH 7.2, 1% BSA, 0.09% sodium azide. Available without BSA, azide and glycerol. See P3272-07X.
PurityPurified by Protein G affinity chromatography.
ImmunogenPepsinogen II purified from human tissue.
SpecificityRecognizes human Pepsinogen II. Does not crossreact with Pepsinogen I.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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