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You are here:Home » Antibodies » Abs to Peptides » Anti -PYY (3-36) (Peptide tyrosine-tyrosine amide, 3-36)

Anti -PYY (3-36) (Peptide tyrosine-tyrosine amide, 3-36)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Peptide tyrosine-tyrosine amide (3-36), or PYY(3-36), is a major metabolite of the gut hormone PYY and is produced by the action of dipeptidyl peptidase IV on PYY in the intestinal brush border and in the circulation. PYY(3-36) is a potent inhibitor of food intake in rats and humans, acting selectively on the Y2 receptor to inhibit orexigenic NPY neurons in the arcuate nucleus, thus disinhibiting anorexigenic POMC neurons. The anorexigenic effect of PYY(3-36) is additive to that of the co-secreted gut hormone GLP-1.
Catalog #P3285-07B
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
Culture MediumRPMI 1640 with 10% fetal calf serum
HybridomaSP2mIL6 myeloma cells with spleen cells from NMRI x BALB/c mice.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No13A143
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenN-terminal fragment of human PYY(3-36) coupled to carrier.
SpecificityRecognizes human PYY(3-36). No cross-reaction with PYY(1-36), PYY from mouse, rat, canine, porcine or NPY.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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