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Anti -PYY (3-36) (Peptide tyrosine-tyrosine amide, 3-36)
Anti -PYY (3-36) (Peptide tyrosine-tyrosine amide, 3-36)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B |
|
| Peptide tyrosine-tyrosine amide (3-36), or PYY(3-36), is a major metabolite of the gut hormone PYY and is produced by the action of dipeptidyl peptidase IV on PYY in the intestinal brush border and in the circulation (1,2). PYY(3-36) is a potent inhibitor of food intake in rats and humans, acting selectively on the Y2 receptor to inhibit orexigenic NPY neurons in the arcuate nucleus, thus disinhibiting anorexigenic POMC neurons (3). The anorexigenic effect of PYY(3-36) is additive to that of the co-secreted gut hormone GLP-1 (4). | | | Catalog # | P3285-07B | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1k | | Clone No | 13A143 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 0.01M phosphate buffer, pH 7.4, 0.5M NaCl and 15mM sodium azide. | | Purity | Purified by Protein A/G affinity chromatography. | | Immunogen | N-terminal fragment of human PYY(3-36) coupled to carrier. | | Specificity | Recognizes human PYY(3-36). No cross-reaction with PYY(1-36), PYY from mouse, rat, canine or porcine, or NPY. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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