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Anti -Period Clock Protein 1 (PER1, RIGUI)
Anti -Period Clock Protein 1 (PER1, RIGUI)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| Catalog # | P3342-02 | | Application(s) | | | Immunohistochemistry (frozen sections (1:500)) | | Western Blot (1:200) | | Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein mediated autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Tranasactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-BMAL1 heterodimers bind to E box regulatory elements and stimulate gene transcription. PER, when complexed with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex. | | CAS Number | N/A | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Mouse | | Concentration | 1mg/ml | | Form | Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa 39-51 (P39SLADDTDANSNG51) of mouse PER1 (period circadian protein 1). | | | Specificity | Recognizes mouse PER1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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