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You are here:Home » Antibodies » Abs to Peripherin » Anti -Peripherin (PRPH, Neurofilament 4, NEF4)

Anti -Peripherin (PRPH, Neurofilament 4, NEF4)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
Peripherin is a Class III intermediate filament subunit found in both the peripheral and central nervous systems, though it is concentrated, as its name suggests, in the neurons of peripheral ganglia and their processes. Antibodies to peripherin can be used in identifying, classifying, and studying neurons in the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig’s disease and some neuronally derived tumors. Peripherin is also a major component of the cytoskeleton of PC12 cells, widely used model system for studies of neuronal differentiation. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin-RDS, a photoreceptor protein associated with retinal degeneration and blindness.
Catalog #P3345-02
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationNot determined
FormSupplied as serum, 0.01% sodium azide
PuritySerum
ImmunogenRecombinant full length rat peripherin
SpecificityRecognizes peripherin, showing no crossreactivity with other Class III intermediate filament proteins. Species crossreactivity: Human and all other mammalian species to date. Results on avian tissues are however not conclusive
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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