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Specifications

Clone Host Grade Applications Polyclonal Chicken Purified B IH IC

Human Perpherin is a 53.651kD (470 aa) expressed in all PNS neurons and some CNS neurons, including a subset of cortical neurons, hippocampal neurons, and ventral horn spinal cord motor neurons. At an ultrastructural level, peripherin immunoreactivity is associated with the neurofilament portion of the cytoskeleton, being particularly abundant in the cell body. Peripherin protein has been shown to undergo upregulation during periods of trophic stress in cultured neurons, and mutations of the peripherin gene have been associated with the neurodegenerative disease amyotrophic lateral sclerosis.
Catalog #	P3345-06A
Applications	Suitable for use in Immunohistochemistry, Immunocytochemistry and Western Blot. Other applications have not been tested.
Recommended Dilutions
	Immunohistochemistry: 1:2000-1:5000 using 2% paraformaldehyde tissues
	Immunocytochemistry: 1:2000-1:5000 using 2% paraformaldehyde cells
	Western Blot: 1:5000-1:10,000
	Optimal dilutions to be determined by the researcher.
Recommended Secondary Antibodies	I1906 IgY, Chicken Pab Rb x Ch
	I1906-10 IgY, Chicken (HRP) Rb x Ch
	I1906-12 IgY, Chicken (FITC) Rb x Ch
	I1906-14 IgY, Chicken (AP) Rb x Ch
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgY
Host	Chicken
Source	Mouse
Concentration	~2mg/ml
Form	Supplied as a liquid in PBS, pH 7.2, 1% BSA, 0.02% sodium azide.
Purity	Purified
Immunogen	Full-length recombinant human peripherin protein.
Specificity	Recognizes human Peropherin.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.