Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Molecular Biology » Growth Factors-Neurotrophins » Persephin (PSP, Neurotrophic Factor)

Persephin (PSP, Neurotrophic Factor)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Human Persephin (PSP) a novel neurotrophic factor is about 40% identical to GDNF and Neurturin (NTN). Persephin, like GDNF and NTN, promotes the survival of ventral midbrain dopaminergic neurons in culture. It also supports the survival of motor neurons in culture. Recombinant Human Persephin is a homodimeric 20.6kD protein consisting of two identical subunits each containing 96 amino acid residues.
Catalog #P3355
Biological Activity Human Persephin induces RET phosphorylation using a concentration range of 0.1-1.0ng/ml. Human Persephin binds to mammalian GFRa4 with the Kd of 100pM. Other members of the GDNF family (Artemin, GDNF and Neurturin) do not bind to mammalian GFRa4.
AA Sequence ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG ARTQHGLALA RLQGQGRAHG GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA ACGCGG
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Country of OriginUSA
Molecular Weight20.6kD
SourceE. coli
Purity98% by SDS-PAGE. Endotoxin: 0.1ng/ug (1EU/ug).
FormSupplied as a lyophilized powder from 0.3X PBS, pH 7.2 Reconstitute with sterile, ddH2O to 0.1-1mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links