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You are here:Home » Antibodies » Abs to Receptors, Estrogen » Anti -PGC-1 beta (Peroxisome Proliferator Activated Receptor gamma Coactivator 1 beta, PPAR gamma Coactivator 1 beta, PPARGC-1 beta, PPARGC1b, PGC1 beta, PGC-1 (beta), PGC-1-beta, PGC1, PGC-1, PGC-1-related Estrogen Receptor alpha Coactivator, PERC)

Anti -PGC-1 beta (Peroxisome Proliferator Activated Receptor gamma Coactivator 1 beta,
PPAR gamma Coactivator 1 beta, PPARGC-1 beta, PPARGC1b, PGC1 beta, PGC-1 (beta),
PGC-1-beta, PGC1, PGC-1, PGC-1-related Estrogen Receptor alpha Coactivator, PERC)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. Ectopic expression of this protein has been shown to lead to increased mitochondrial number and basal oxygen consumption.
Catalog #P3363-04
Cellular Localization Nuclear (may also see some cytoplasmic localization).
Positive Control Human cortical neurons
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5mg/ml. Band at ~113kD is observed in huma skeletal muscle and HeLa nuclear extracts, and in A673 and DU145 whole cell extracts. Many non-specific bands are also observed; thus, a true negative control is strongly recommended to determine the exact band of interest in your positive samples.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid Tris-glycine containing 150mM sodium chloride and 0.05% sodium azide
PurityPurified by immunoaffinity chromatography
ImmunogenA 385 amino acid recombinant protein made to the N-terminal region of the human PGC-1 beta protein. [Swiss-Prot# Q86YN6]. Homology: 76% identity with mouse and rat.
82% identity with equine.
73% identity with canine.
SpecificityRecognizes human PGC-1 beta
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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