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Anti -Pgp (P-Glycoprotein, MDR Protein, Multi Drug Resistance Associated Protein)
Anti -Pgp (P-Glycoprotein, MDR Protein, Multi Drug Resistance Associated Protein)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
B IH |
|
| P-glycoprotein, a plasma membrane associated molecule which is important in mediating resistance to cytotoxic drugs. In normal tissues P-glycoprotein is expressed in liver, kidney, colon, adrenal gland and lung. In malignant conditions increased expression of P-glycoprotein may be associated with multi-drug resistance, and the detection of this can have important consequences for treatment. | | | Catalog # | P3365-03B | | Applications | Suitable for use in Immunohistochemistry and Western Blot. | | Other applications have not been tested. | | Recommended Dilutions | | | Immunohistochemistry (Frozen/paraffin): 1:10-1:20. Requires protein digestion pre-treatment of paraffin sections with 0.1% pronase for 10 minutess. | | Optimal working dilutions to be determined by researcher. | | Hybridoma | Spleen cells from immunized BALB/c mice were fused with the cells of the SP2/0 mouse myeloma cell line. | | Recommended Positive Control | Liver, kidney or lung tissue | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 3H2833(JSB-1) | | Host | Mouse | | Source | Human | | Concentration | Not Determined | | Form | Supplied as a liquid in PBS, 1% BSA, 0.09% sodium azide. | | Purity | Supernatant | | Immunogen | Multi drug resistant chinese hamster ovary cell line, CHrC5. | | Specificity | Recognizes human P-glycoprotein at 170-180kD. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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