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You are here:Home » Antibodies » Abs to Carbohydrates, Glycoproteins » Anti -Pgp (P-Glycoprotein, MDR Protein, Multi Drug Resistance Associated Protein)

Anti -Pgp (P-Glycoprotein, MDR Protein, Multi Drug Resistance Associated Protein)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant B IH
P-glycoprotein, a plasma membrane associated molecule which is important in mediating resistance to cytotoxic drugs. In normal tissues P-glycoprotein is expressed in liver, kidney, colon, adrenal gland and lung. In malignant conditions increased expression of P-glycoprotein may be associated with multi-drug resistance, and the detection of this can have important consequences for treatment.
Catalog #P3365-03B
ApplicationsSuitable for use in Immunohistochemistry and Western Blot.
Other applications have not been tested.
Recommended Dilutions
Immunohistochemistry (Frozen/paraffin): 1:10-1:20. Requires protein digestion pre-treatment of paraffin sections with 0.1% pronase for 10 minutess.
Optimal working dilutions to be determined by researcher.
HybridomaSpleen cells from immunized BALB/c mice were fused with the cells of the SP2/0 mouse myeloma cell line.
Recommended Positive ControlLiver, kidney or lung tissue
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No3H2833(JSB-1)
HostMouse
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in PBS, 1% BSA, 0.09% sodium azide.
PuritySupernatant
ImmunogenMulti drug resistant chinese hamster ovary cell line, CHrC5.
SpecificityRecognizes human P-glycoprotein at 170-180kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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