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Abs to Multi Drug Resistance (MDR)
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Anti -P-Glycoprotein (p170, Pgp, MDR Protein, Multi Drug Resistance Associated Protein)
Anti -P-Glycoprotein (p170, Pgp, MDR Protein, Multi Drug Resistance Associated Protein)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Ascites |
IH |
|
| P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas. | | | Catalog # | P3365-04B | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (formalin fixed paraffin embedded): 1:25-1:50 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Adrenal | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 11E317 | | Host | Mouse | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Ascites | | Immunogen | SDS-solublized plasma membranes of multidrug-resistant Chinese hamster ovary (CHRB30) and human (CEM/VLB500). Cellular Localization: Cell membrane. | | Specificity | Recognizes human p170/p-Glycoprotein. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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