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You are here:Home » Antibodies » Abs to Hypoxia » Anti -PHD2 (Prolyl Hydroxylase 2, Prolyl Hydroxylase Comain-containing Protein 2, C1orf12, ECYT3, Egl Nine Homolog 1, EGLN1, Hypoxia-inducible Factor Prolyl Hydroxylase 2, HIF-prolyl Hydroxylase 2, HIFPH2, HIF-PH2, HPH2, HPH-2, PNAS-118, PNAS-137, SM20, SM-20,

Anti -PHD2 (Prolyl Hydroxylase 2, Prolyl Hydroxylase Comain-containing Protein 2, C1orf12,
ECYT3, Egl Nine Homolog 1, EGLN1, Hypoxia-inducible Factor Prolyl Hydroxylase 2,
HIF-prolyl Hydroxylase 2, HIFPH2, HIF-PH2, HPH2, HPH-2, PNAS-118, PNAS-137, SM20, SM-20,

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH
Prolyl hydroxylase 2 (PHD2) is a 46kD enzyme expressed abundantly in all tissues with the highest expression in testis. Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex, consisting of an alpha and beta subunit, which plays a key role in coordinating the cellular response to hypoxia. During normal oxygen conditions, the alpha subunit of HIF-1 is rapidly degraded, however when hypoxia occurs this degradation is suppressed and HIF-1 activates the transcription of various genes important for survival and adaptation to hypoxia. Prolyl hydroxylase 2 catalyses the hydroxylation of specific prolyl residues within the HIF-1 alpha subunit, thereby targeting this subunit for degradation.
Catalog #P3374-04
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions
Immunohistochemistry: paraffin sections
Optimal dilutions to be determined by the researcher.
Immunohistochemistry Positive controlHuman Testis
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Labeled with horseradish peroxidase (HRP). Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. HRP conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG1
Clone No366G/76/3
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.01% thiomersal. Lableled with HRP.
PurityPurified by Protein G affinity chromatography.
ImmunogenPHD2 aa 1-24
SpecificityRecognizes human prolyl hydroxylase 2 (PHD2).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEgl Nine Homolog 1 (C. elegans), DKFZp761F179, EC=1.14.11.-


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