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You are here:Home » Biochemicals » Biochem-Mycotoxins » Phomopsin A

Phomopsin A


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Phomopsin A is an acidic 13-membered cyclic hexapeptide-like metabolite with three unusual amino acids linked in an "ansa" macrocycle with a three amino acid "tail", terminating in a dicarboxylic acid. Phomopsin A is a potent mycotoxin produced by the fungus Phomopsis leptostromiformis and is the causative agent of lupinosis in livestock fed infected lupins. Phomopsin A is an important bioprobe for understanding cellular structural proteins. It acts by selectively binding to dimeric tubulin, inhibiting the formation of the microtubule spindle to block cell division. Phomopsin A binds to tubulin at a site overlapping that of vinblastine and maytansine. Uniquely, phomopsin A protects tubulin from decay.
Catalog #P3970
Source Phomposis leptostromiformis MST-FP2068
Apperance Supplied as a white solid.
Solubility Soluble in ethanol, methanol, DMF or DMSO. Slightly soluble in water.
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
CAS Number64925-80-0
Molecular FormulaC36H45ClN6O12
Molecular Weight789.2
SourcePhomposis leptostromiformis MST-FP2068
Purity (HPLC)~98%
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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