Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Biochemicals » Biochem-Mycotoxins » Phomopsin A

Phomopsin A

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Phomopsin A is an acidic 13-membered cyclic hexapeptide-like metabolite with three unusual amino acids linked in an "ansa" macrocycle with a three amino acid "tail", terminating in a dicarboxylic acid. Phomopsin A is a potent mycotoxin produced by the fungus Phomopsis leptostromiformis and is the causative agent of lupinosis in livestock fed infected lupins. Phomopsin A is an important bioprobe for understanding cellular structural proteins. It acts by selectively binding to dimeric tubulin, inhibiting the formation of the microtubule spindle to block cell division. Phomopsin A binds to tubulin at a site overlapping that of vinblastine and maytansine. Uniquely, phomopsin A protects tubulin from decay.
Catalog #P3970
Source Phomposis leptostromiformis MST-FP2068
Apperance Supplied as a white solid.
Solubility Soluble in ethanol, methanol, DMF or DMSO. Slightly soluble in water.
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
CAS Number64925-80-0
Molecular FormulaC36H45ClN6O12
Molecular Weight789.2
SourcePhomposis leptostromiformis MST-FP2068
Purity (HPLC)~98%
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links