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You are here:Home » Antibodies » Abs to Tumor Suppressors » Anti -PHLPP (PH Domain and Leucine-rich Repeat Protein Phosphatase, PH Domain Leucine-rich Repeat Protein Phosphatase, PH Domain Leucine-rich Repeat-containing Protein Phosphatase, PHLPP1, KIAA0606 Protein, Pleckstrin Homology Domain-containing Family E Protein

Anti -PHLPP (PH Domain and Leucine-rich Repeat Protein Phosphatase, PH Domain Leucine-rich
Repeat Protein Phosphatase, PH Domain Leucine-rich Repeat-containing Protein Phosphatase,
PHLPP1, KIAA0606 Protein, Pleckstrin Homology Domain-containing Family E Protein

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IP
Located on chromosome 18 and called PH domain Leucine-rich repeat Protein Phosphatase (PHLPP), the tumor suppressor is described in the April 1, 2005 issue of the journal Molecular Cell. The scientists demonstrated that PHLPP deletes a phosphate molecule, causing termination of cell-growth signaling by a protein called Akt that controls the balance between cell growth leading to cancer and cell death that prevents tumor formation. PHLPP levels are markedly reduced in several colon cancer and gliobastoma human cell lines that had elevated Akt phosphorylation.
Catalog #P4070-87
ApplicationsSuitable for use in Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormTris-citrate/phosphate buffer with 0.09% Sodium Azide
PurityPurified by immunoaffinity chromatography.
ImmunogenThe epitope recognized maps to a region between residues 1050 and 1100 of human PH Domain and Leucine Rich Repeat Protein Phosphatase using the numbering given in entry NP_919431.1 (GeneID 23239).
SpecificitySpecies Crossreactivity: This antibody crossreacts with human. Other species have not been tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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