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You are here:Home » Antibodies » Abs to Enzymes, Phosphodiesterase » Anti -Phosphodiesterase 1C, CT (PDE1C, Calcium/Calmodulin-Dependent 3',5'-Cyclic Nucleotide Phosphodiesterase 1C, Cam-PDE 1C, hCam-3)

Anti -Phosphodiesterase 1C, CT (PDE1C, Calcium/Calmodulin-Dependent 3',5'-Cyclic
Nucleotide Phosphodiesterase 1C, Cam-PDE 1C, hCam-3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
Phosphodiesterase 1C (PDE1C) is a subtype of the PDE1 enzyme. PDE1C is activated by calmodulin binding in the presence of calcium, and degrades the cyclic nucleotides cAMP and cGMP. A number of PDE1C isoforms exist, each with different affinities for cAMP and cGMP. They have a range of molecular weights from 65-70kD. PDE1C is a major regulator of smooth muscle cell (SMC) proliferation in humans, and plays an important role in the development of organs containing smooth muscle. PDE1C may also have a role in olfaction, regulation of sperm function and neuronal signaling.
Catalog #P4071-99D
Inhibition of PDE1C may prove beneficial in the treatment of diseases such as atherosclerosis and pulmonary hypertension where excessive SMC proliferation occurs.
ApplicationsSuitable for use in Immunohistochemistry (paraffin). Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 2-10ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control TissueThyroid
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH7.7, 1% BSA, 0.01% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the C-terminal domain of human phosphodiesterase 1C (KLH).
SpecificityRecognizes an epitope within the C-terminal region of human PDE1C. Species sequence homology: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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