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Anti -Phosphodiesterase 1C, CT (PDE1C, Calcium/Calmodulin-Dependent 3',5'-Cyclic Nucleotide Phosphodiesterase 1C, Cam-PDE 1C, hCam-3)
Anti -Phosphodiesterase 1C, CT (PDE1C, Calcium/Calmodulin-Dependent 3',5'-Cyclic
Nucleotide Phosphodiesterase 1C, Cam-PDE 1C, hCam-3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IH |
|
| Phosphodiesterase 1C (PDE1C) is a subtype of the PDE1 enzyme. PDE1C is activated by calmodulin binding in the presence of calcium, and degrades the cyclic nucleotides cAMP and cGMP. A number of PDE1C isoforms exist, each with different affinities for cAMP and cGMP. They have a range of molecular weights from 65-70kD. PDE1C is a major regulator of smooth muscle cell (SMC) proliferation in humans, and plays an important role in the development of organs containing smooth muscle. PDE1C may also have a role in olfaction, regulation of sperm function and neuronal signaling. | | | Catalog # | P4071-99D | | Inhibition of PDE1C may prove beneficial in the treatment of diseases such as atherosclerosis and pulmonary hypertension where excessive SMC proliferation occurs. | | Applications | Suitable for use in Immunohistochemistry (paraffin). Other applications not tested. | | Recommended Dilution | Immunohistochemistry (paraffin): 2-10ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control Tissue | Thyroid | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH7.7, 1% BSA, 0.01% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the C-terminal domain of human phosphodiesterase 1C (KLH). | | Specificity | Recognizes an epitope within the C-terminal region of human PDE1C. Species sequence homology: mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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