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You are here:Home » Antibodies » Abs to Enzymes, Phosphodiesterase » Anti -Phosphodiesterase 2A, NT (PDE2A, cGMP-Dependent 3',5'-Cyclic Phosphodiesterase, Cyclic GMP-Stimulated Phosphodiesterase, CGS-PDE, cGSPDEm)

Anti -Phosphodiesterase 2A, NT (PDE2A, cGMP-Dependent 3',5'-Cyclic Phosphodiesterase,
Cyclic GMP-Stimulated Phosphodiesterase, CGS-PDE, cGSPDEm)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
PDE2A is a 100kD cyclic nucleotide phosphodiesterase (PDE). Three isoforms of PDE2A have been reported (PDE2A1, PDE2A2, and PDE2A3) which arise from a single gene by alternative splicing events. PDE2A can degrade both cAMP and cGMP, but degrades cGMP with greater efficacy.
Catalog #P4072-01D
PDE2A is expressed in a variety of tissue types, with greatest expression in the brain, where it is localised in the cerebellum and neocortex. PDE2A has been implicated in penile erectile dysfunction and in the regulation of fluid and inflammatory cell transport across the endothelial cell barrier.
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 15-25ug/ml
Requires antigen retrieval using heat treatment prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher.
Positive Control TissueKidney
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH7.7, 0.09% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the N-terminal region of human phosphodiesterase 2A (KLH).
SpecificityRecognizes an epitope within the N-terminal (NT) region of human phosphodiesterase 2A. Species Crossreactivity: rat. Does not cross react with mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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