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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified B

The phosphodiesterase type-3 (PDE3) family is comprised of 2 isoforms, PDE3A and PDE3B. Phosphodiesterases (PDE) are crucial in the regulation of the intracellular level of the second messenger cAMP by hydrolyzing cAMP to 5’AMP. PDE3B has two splice variants that are expressed in adipocyte tissue, hepatocyte, kidney, spermatocytes and embryonic neuroepithelium. Both PDE3A and PDE3B are potential targets for the treatment of obesity.
Catalog #	P4072-02S
Applications	Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution	Western Blot: 1-4ug/ml
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Mouse
Concentration	~0.5mg/ml
Form	Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
Purity	Purified by affinity chromatography.
Immunogen	Synthetic peptide surrounding aa 948 of mouse PDE3B.
Specificity	Recognizes mouse PDE3B. Species crossreactivity: mouse, rat.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names	PDE3B, phosphodiesterase type-3