Anti -Phosphodiesterase 4B (PDE4B, PDEIVB, cAMP-specific 3',5'-cyclic Phosphodiesterase
4B, DPDE4, PDE32)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
|
| This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. | | | Catalog # | P4072-03S1 | | Applications | Suitable for use in ELISA and Western Blot. Other applications have not been tested. | | Recommended Dilutions | | | Peptide ELISA Titer: 1:8000 | | Western Blot: 0.5-1ug/ml ~85kD band observed in Mouse Brain lysates (calculated MW of 83.3kD according to Human NP_002591.2 and 82.1kD according to Mouse NP_062814.2). In transfected HEK293 transiently expressing Human PDE4B a band of approx. 85kD is observed. This band is not observed in the non-transfected HEK293. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide. | | Purity | Purified by peptide affinity chromatography. | | Immunogen | Synthetic peptide corresponding to C-DIDIATEDKSPVDT, from the C Terminus of human Phosphodiesterase 4B (NP_002591.2; NP_001032418.1; NP_001032416.1; NP_001032417.1). | | Specificity | Recognizes mouse Phosphodiesterase 4B. This antibody is expected to recognise all reported isoforms (NP_002591.2, NP_001032418.1, NP_001032416.1 and NP_001032417.1). Species sequence homology: human, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Phosphodiesterase 4B, cAMP-specific, DKFZp686F2182, EC=3.1.4.17, MGC126529, PDE4B5 |
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