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You are here:Home » Antibodies » Abs to Enzymes, Phosphodiesterase » Anti -Phosphodiesterase 4D (Phosphodiesterase 4D cAMP Specific, Phosphodiesterase-4D, PDE4D, cAMP Specific 3' 5' Cyclic Phosphodiesterase 4D, cAMP Specific Phosphodiesterase 4D, cAMP Specific Phosphodiesterase PDE4D, Cyclic AMP Phosphodiesterase, Dunce-like Pho

Anti -Phosphodiesterase 4D (Phosphodiesterase 4D cAMP Specific, Phosphodiesterase-4D,
PDE4D, cAMP Specific 3' 5' Cyclic Phosphodiesterase 4D, cAMP Specific Phosphodiesterase
4D, cAMP Specific Phosphodiesterase PDE4D, Cyclic AMP Phosphodiesterase, Dunce-like Pho

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
Catalog #P4072-03Y
ApplicationsSuitable for use in ELISA and Western Blot. Other applications have not been tested.
Recommended Dilutions
Peptide ELISA Titer: 1:128,000
Western Blot: 0.1-0.3ug/ml ~70+80+90kD bands observed in lysates of cell line A549. In transfected COS1 transiently expressing PDE4D1 and PDE4D3 bands of ~68kD and 95kD are observed. These bands are not observed in the untransfected COS1. In transfected HEK293 transiently expressing PDE4D2 multi bands from ~55kD-80kD are observed. These bands are not observed in the non-transfected HEK293. Calculated MW of 91.1kD according to PDE4D1 (NP_001098101.1), 76.5kD according to PDE4D2 (NP_006194.2) and 84.7kD according to PDE4D3 (NP_001159371.1).
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
PurityPurified by peptide affinity chromatography.
ImmunogenSynthetic peptide corresponding to QPEACVIDDRSPDT, from the C Terminus of human Phosphodiesterase 4D (NP_001098101.1; NP_006194.2; NP_001159371.1).
SpecificityRecognizes human Phosphodiesterase 4D. Not expected to recognize isoform 4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesphosphodiesterase 4D, FLJ97311, DKFZp686M11213, phosphodiesterase 4D, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E3), dunce-like phosphodiesterase E3, cAMP-specific phosphodiesterase PDE4D6, cAMP-specific phosphodiesterase 4D, STRK1, PDE4


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