Anti -Phosphodiesterase 4D (Phosphodiesterase 4D cAMP Specific, Phosphodiesterase-4D,
PDE4D, cAMP Specific 3' 5' Cyclic Phosphodiesterase 4D, cAMP Specific Phosphodiesterase
4D, cAMP Specific Phosphodiesterase PDE4D, Cyclic AMP Phosphodiesterase, Dunce-like Pho
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
|
| This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins. | | | Catalog # | P4072-03Y | | Applications | Suitable for use in ELISA and Western Blot. Other applications have not been tested. | | Recommended Dilutions | | | Peptide ELISA Titer: 1:128,000 | | Western Blot: 0.1-0.3ug/ml ~70+80+90kD bands observed in lysates of cell line A549. In transfected COS1 transiently expressing PDE4D1 and PDE4D3 bands of ~68kD and 95kD are observed. These bands are not observed in the untransfected COS1. In transfected HEK293 transiently expressing PDE4D2 multi bands from ~55kD-80kD are observed. These bands are not observed in the non-transfected HEK293. Calculated MW of 91.1kD according to PDE4D1 (NP_001098101.1), 76.5kD according to PDE4D2 (NP_006194.2) and 84.7kD according to PDE4D3 (NP_001159371.1). | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide. | | Purity | Purified by peptide affinity chromatography. | | Immunogen | Synthetic peptide corresponding to QPEACVIDDRSPDT, from the C Terminus of human Phosphodiesterase 4D (NP_001098101.1; NP_006194.2; NP_001159371.1). | | Specificity | Recognizes human Phosphodiesterase 4D. Not expected to recognize isoform 4. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | phosphodiesterase 4D, FLJ97311, DKFZp686M11213, phosphodiesterase 4D, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E3), dunce-like phosphodiesterase E3, cAMP-specific phosphodiesterase PDE4D6, cAMP-specific phosphodiesterase 4D, STRK1, PDE4 |
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