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You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -Phosphodiesterase 6 beta (Phosphodiesterase 6B, Phosphodiesterase 6B cGMP-specific Rod beta, PDE6 beta, PDE6B, Congenital Stationary Night Blindness 3 Autosomal Dominant, CSNB3, Dunce-like Phosphodiesterase 4, DPDE4, GMP-PDE beta, PDEB, Rd1, Rod cGMP-spec

Anti -Phosphodiesterase 6 beta (Phosphodiesterase 6B, Phosphodiesterase 6B cGMP-specific
Rod beta, PDE6 beta, PDE6B, Congenital Stationary Night Blindness 3 Autosomal Dominant,
CSNB3, Dunce-like Phosphodiesterase 4, DPDE4, GMP-PDE beta, PDEB, Rd1, Rod cGMP-spec

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH IF
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding difference isoforms have been found for this gene.
Catalog #P4072-06B1
ApplicationsSuitable for use in Immunofluorescence, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 2ug/ml
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa20-36 of mouse and bovine PDE6 beta (HQYFG(K/R)KLSPENVAGAC). Cellular Localization: Plasma membrane
SpecificityRecognizes mouse Phosphodiesterase 6 beta at ~90kD. Species Sequence Homology: bovine, human, canine
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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