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You are here:Home » Antibodies » Abs to Enzymes, Phosphodiesterase » Anti -Phosphodiesterase 9A (Phosphodiesterase-9A, PDE9A, cGMP Specific 3' 5' Cyclic Phosphodiesterase Type 9, CGMP-specific 3'5'-cyclic Phosphodiesterase Type 9, EC 3.1.4.35, High-affinity cGMP-specific 3'5'-cyclic Phosphodiesterase 9A, HSPDE9A2)

Anti -Phosphodiesterase 9A (Phosphodiesterase-9A, PDE9A, cGMP Specific 3' 5' Cyclic
Phosphodiesterase Type 9, CGMP-specific 3'5'-cyclic Phosphodiesterase Type 9, EC 3.1.4.35,
High-affinity cGMP-specific 3'5'-cyclic Phosphodiesterase 9A, HSPDE9A2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
Phosphodiesterase 9A is a cGMP-specific phosphodiesterase. PDE9A activity is inhibited by zaprinast, but it is insensitive to rolipram, vinpocetine, SKF-94120, dipyridamole, and IBMX. More than 20 alternatively spliced variants have been reported (Rentero et al. 2003). PDE9A has been implicated in penile erectile dysfunction, as well as in functional disturbances in which intraneuronal signal transmission via second messengers are important in the pathophysiology (example, bipolar affective disorder). PDE9A is the only cGMP-specific PDE with significant expression in the forebrain, and as such is likely to function in NO-cGMP signaling.
Catalog #P4072-09A1
Positive Control Spleen
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by peptide immunoaffinity chromatography.
ImmunogenSynthetic peptide - KLH conjugated (exact sequence is proprietary information). Epitope: internal domain of human
SpecificityThis antibody is specific to the human PDE9A protein. Species Crossreactivity: Human. Other species not yet tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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