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You are here:Home » Antibodies » Antibodies-Enzymes, Phospholipase » Anti -PLA2G4A, ID (Cytosolic Phospholipase A2, cPLA2, Phospholipase A2 Group IVA, Phospholipase A2, Phosphatidylcholine 2-acylhydrolase, Lysophospholipase, PLA2G4, CPLA2)

Anti -PLA2G4A, ID (Cytosolic Phospholipase A2, cPLA2, Phospholipase A2 Group IVA,
Phospholipase A2, Phosphatidylcholine 2-acylhydrolase, Lysophospholipase, PLA2G4, CPLA2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH FC IF
PLA2G4A is a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Catalog #P4074-03A
ApplicationsSuitable for use in Immunofluorescence, Flow Cytometry, Immunohistochemistry, ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Immunohistochemistry (FFPE): 1:10-1:50
Immunofluorescence: 1:10-1:50
Flow Cytometry: 1:10-1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenKLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 513-541 in the central region of human PLA2G4A, UniProt Accession #NP_077734.1; P47712. Species sequence homology: Chicken, mouse, rat, zebrafish
SpecificityRecognizes human PLA2G4A.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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