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You are here:Home » Antibodies » Antibodies-Enzymes, Phospholipase » Anti -c-Phospholipase A2 (Cytosolic PLA2, cPLA2)

Anti -c-Phospholipase A2 (Cytosolic PLA2, cPLA2)


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Clone Host Grade Applications
Polyclonal Rabbit Purified B
Cytosolic phospholipase A2 (cPLA2) is a ubiquitously distributed enzyme that catalyzes the hydrolysis of the sn-2 acyl bond of glycerolipids to produce lysophospholipids and the release of arachidonic acid. cPLA2 has been implicated in diverse cellular responses such as mitogenesis, differentiation, inflammation and cytotoxicity. Calcium binding to the Nterminal CalB domain of cPLA2 promotes the translocation of cPLA2 from cytosol to membrane, where cPLA2 cleaves arachidonic acid from natural membrane. Phosphorylation of cPLA2 by MAPK (p42/44 and p38) at serine 505 and serine 727 stimulates its catalytic activity.
Catalog #P4074-03M
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1-5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, 0.05% sodium azide.
PurityPurified by ammonium sulfate precipitation.
ImmunogenSynthetic peptide corresponding to aa152-179 of mouse cPLA2. Sequence: D-Q-E-K-T-F-R-Q-Q-R-K-E-N-I-K-E-N-M-K- K-L-L-G-P-K-K-S-E.
SpecificityRecognizes mouse cPLA2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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