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You are here:Home » Antibodies » Abs to Enzymes, Phospholipase » Anti -Phospholipase C, gamma 1 (Phosphoinositide Phospholipase C-gamma-1, PLCgamma1, PLC-gamma-1, PLCg1, PLC1, NCKAP3, 1-Phosphatidylinositol-4,5-bisphosphate Phosphodiesterase gamma-1, Phospholipase C-II, PLC-II, PLC148, PLC-148)

Anti -Phospholipase C, gamma 1 (Phosphoinositide Phospholipase C-gamma-1, PLCgamma1,
PLC-gamma-1, PLCg1, PLC1, NCKAP3, 1-Phosphatidylinositol-4,5-bisphosphate
Phosphodiesterase gamma-1, Phospholipase C-II, PLC-II, PLC148, PLC-148)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
PLCg1 hydrolyzes phosphatidylinositol-4,5-bisphosphate to generate inositol-1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG), which are implicated in the mobilization of intracellular Ca2+ and protein kinase C activation, respectively. Unlike other PLC isotypes, the protein contain two src homology (SH) 2 domains and one SH3 domain between the X and Y catalytic domains, and these three domains have been implicated in the regulation of cellular proliferation and growth. The protein also has a key function in the regulation of growth hormone-mediated signalling by negatively regulating Jak2 activation. Human PLCgâ¡ gene maps to the chromosome 20 in the region 20q12-q13.1.
Catalog #P4074-42E
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlA431 cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human PLCg1 around the phosphorylation site of tyrosine 783 (G-F-YP-V-E).
SpecificityRecognizes human PLCg1. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEC=3.1.4.11


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