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You are here:Home » Antibodies » Abs to Enzymes, Phospholipase » Anti -PLCG1 (1-phosphatidylinositol-4,5-bisphosphate Phosphodiesterase gamma-1, PLC-148, Phosphoinositide Phospholipase C-gamma-1, Phospholipase C-II, PLC-II, Phospholipase C-gamma-1, PLC-gamma-1, PLC1)

Anti -PLCG1 (1-phosphatidylinositol-4,5-bisphosphate Phosphodiesterase gamma-1, PLC-148,
Phosphoinositide Phospholipase C-gamma-1, Phospholipase C-II, PLC-II, Phospholipase
C-gamma-1, PLC-gamma-1, PLC1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites B IP
Phospholipase C gamma 1 is a tryosine kinase substrate for many receptor and nonreceptor tyrosine kinases. Activation of the enzyme produces two second messenger molecules, inositol 1,4,5-triphosphate and diacylglycerol, which provoke the mobilization of intracellular Ca2+ and activation of protein kinase C. Although the mammalian genome encodes 10 known phosphoinositide specific PLCs, only the gamma 1 and gamma 2 isoforms are regulated by tyrosine kinase activity. PLC beta isoform activity is controlled by heterotrimeric G protein coupled receptors, while the mechanism of regulation of PLC gamma activity is unknown.
Catalog #P4074-43C
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:4,000
Immunoprecipitation: 1ul/400ul lysates.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a, k
Clone No10K322
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid.
PurityAscites
ImmunogenRecombinant human protein purified from E.coli.
SpecificityRecognizes human Phospholipase C gamma 1. Species Crossreactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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