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You are here:Home » Antibodies » Abs to Amino Acids » Anti -Phosphotyrosine

Anti -Phosphotyrosine

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E B FC IF
Protein tyrosine phosphorylation has been the subject of intense investigation for over two decades. Tyrosine phosphorylation is catalyzed by members of the tyrosine kinase superfamily. To date, approximately 90 members of this superfamily have been identified in the human genome. Levels of phosphorylation of tyrosine residues within cellular proteins are observed to increase in response to growth factors, cytokines, insulin, extracellular matrix components, and other stimuli. Tyrosine phosphorylation has several effects, including the regulation of enzyme activity, as well as the localization of enzyme activity through the generation of docking sites for proteins bearing SH2 domains.
Catalog #P4078-11
ApplicatonsSuitable for use in Western Blot, ELISA, Flow Cytometry, Immunofluorescence and purification of phosphorylated proteins. Other applications not tested.
Recommended DilutionOptimal dilution determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No2Q264
HostMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.1% sodium azide before the addition of glycerol to 40%.
PurityPurified IgG
ImmunogenPhosphotyrosine conjugated to KLH.
SpecificityReacts specifically with phosphotyrosine or close phosphotyrosine analogs. No reactivity to ribose phosphates, phosphoserine, phosphothreonine, phosphoseryl-BSA and a variety of nucleotides (e.g. AMP, ATP).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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